Type I IgE-mediated hypersensitivity reaction. Release of histamine and other agents causes: capillary leak; wheeze; cyanosis; oedema (larynx, lids, tongue, lips); urticaria. More common in atopic individuals. An anaphylactoid reaction results from direct release of mediators from inflammatory cells, without involving antibodies, usually in response to a drug, eg acetylcysteine.
Common precipitants
Drugs, eg penicillin, and contrast media in radiology
Latex
Stings, eggs, fish, peanuts, strawberries, semen
Signs and symptoms
Itching, erythema, urticaria, oedema
Wheeze, laryngeal obstruction, cyanosis
Tachycardia, hypotension
No comments:
Post a Comment